매스틱의 구강암세포 성장 억제효과
Anticancer effect of mastic on human oral cancer cells
김지혜, 최중혁, 정윤숙, 조민정, 이영은, 박동옥, 송근배,
소속 상세정보
김지혜 ( Kim Ji-Hye ) - 경북대학교 치의학전문대학원 예방치과학교실
최중혁 ( Choi Jung-Hyuck ) - 경북대학교 치의학전문대학원 예방치과학교실
정윤숙 ( Jung Yun-Sook ) - 경북대학교 치의학전문대학원 예방치과학교실
조민정 ( Jo Min-Jeong ) - 경북대학교 치의학전문대학원 예방치과학교실
이영은 ( Lee Young-Eun ) - 대구보건대학교 치위생과
박동옥 ( Park Dong-Ok ) - 대구보건대학교 치위생과
송근배 ( Song Keun-Bae ) - 경북대학교 치의학전문대학원 예방치과학교실
KMID : 0355420160400030143
Abstract
Objectives: Mastic is a resinous extract from the stem and main leaves of Pistacia lentiscus, grown only in the Chios island of Greece. Mastic has antibacterial, anti-inflammatory, anticancer, and anti-ulcer activities. Although mastic has been widely studied, its inhibitory effect against cancer cells, especially oral cancer cells, has not been elucidated. The purpose of this study was to assess the anticancer effects of mastic on human oral cancer YD-10B cells.
Methods: YD-10B cells were cultured in 0, 1, 2, 5, and 10 mg/mL mastic for 24 h. Cell count, viability, morphology, colony-forming assay, and DAPI staining were analyzed.
Results: Mastic treatment of YD-10B cells resulted in a dose-dependent inhibition of cell growth, and almost all the cells in the 10 mg/mL culture were dead (P<0.05). Mastic treatment induced a morphological change and nuclear fragmentation in the YD-10B cells, and inhibited colony formation of YD-10B cells in a dose-dependent manner.
Conclusions: These results indicate that mastic exhibited anticancer effects on the YD-10B cells through changes in cell morphology and apoptosis.
키워드
Apoptosis; Mastic; Oral cancer
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